Selozok – Bull Selozok (extended release coated tablet) – My Life
- 1 Presentation Selozok
- 2 Composition Selozok
- 3 What is Selozok
- 4 expected action Selozok
- 5 Contraindications and risk Selozok
- 6 Precautions and warnings Selozok
- 7 Interactions of Selozok
- 8 Selozok use in pregnancy and breastfeeding
- 9 Storage, manufacturing date, expiry date and physical aspect of Selozok
- 10 Dosage, dosage and usage instructions Selozok
- 11 Adverse reactions Selozok
- 12 Overdose Selozok
Active ingredients: metoprolol succinatefalsetrue
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Presentation SelozokOral use
Coated tablets for controlled release 25 mg, 50 mg or 100 mg in packages of 20, 30 or 60 tablets.
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25 mg SELOZOK: Each coated controlled release tablet contains 23.75 mg of metoprolol succinate equivalent to 25 mg metoprolol tartrate.
50 mg SELOZOK: Each coated controlled release tablet contains 47.5 mg of metoprolol succinate equivalent to 50 mg metoprolol tartrate.
SELOZOK 100 mg: Each coated controlled release tablet contains 95 mg of metoprolol succinate equivalent to 100 mg metoprolol tartrate.
Excipients: silicon dioxide, ethyl cellulose, microcrystalline cellulose, hyprolose, hypromellose, sodium stearyl fumarate, macrogol, titanium dioxide, and paraffin.
1. What is this drug is indicated?
What is Selozok
SELOZOK It is indicated for the treatment of hypertension (high blood pressure) - lowering blood pressure, and cardiovascular morbidity and mortality risk of coronary origin (including sudden death); angina pectoris; Adjuvant therapy of symptomatic chronic heart failure, mild to severe: increased survival, reduced hospitalization, improved left ventricular function, improvement in functional class New York Heart Association (NYHA) and improved quality of life; Heart rhythm disorders, especially including supraventricular tachycardia; Maintenance treatment after myocardial infarction; functional cardiac disorders with palpitations; Prevention of migraine attacks.DO NOT STOP NOW ... YOU ARE AFTER THAT ADVERTISING;)
2. How this medicine works?
expected action Selozok
SELOZOK It belongs to a class of drugs called beta-blockers, which works by reducing the strain on the heart.
SELOZOK is a coated controlled release tablet which releases selozok for a controlled time, ensuring an effect for more than 24 hours. In general, the onset of effect is observed within a few hours, even at lower doses of metoprolol. The maximum antihypertensive effect of metoprolol any dose range will be reached after a week of therapy.DO NOT STOP NOW ... YOU ARE AFTER THAT ADVERTISING;)
3. When should I not use this medicine?
Contraindications and risk Selozok
You should not use SELOZOK in the following situations: if you are allergic to metoprolol, the other components of the formula or other beta-blockers; II atrioventricular block or class III heart failure patients not compensated unstable (i.e. pulmonary edema [water lung] hypoperfusion [low oxygen in body organs] or hypotension [low pressure]), and patients with continuous or intermittent inotropic therapy acting through beta receptor agonist, clinically relevant sinus bradycardia, the sino-atrial node syndrome (unless you make use of a permanent pacemaker), cardiogenic shock and severe peripheral arterial disease; metoprolol should not be administered to patients with suspected acute myocardial infarction, while the heart rate is < 45 beats / minute, the PQ interval is > 0.24 seconds or systolic blood pressure is < 100 mmHg.DO NOT STOP NOW ... YOU ARE AFTER THAT ADVERTISING;)
4. What should I know before using this medicine?
Precautions and warnings Selozok
SELOZOK It should be used with caution in the following situations: if you are being treated for asthma; if you have a pre-existing change in driving moderate degree of A-V (conduction of the electrical impulse between atrium and ventricle, causing the heart to beat at the correct rhythm); develop increased bradycardia (decreased frequency of heart beats); if carrier pheochromocytoma (tumor type, generally benign, located in the adrenal gland).
Treatment with SELOZOK It should not be stopped abruptly. If you need to discontinue treatment SELOZOK, It is recommended to be done gradually.
Before surgery, tell your doctor or dentist that you are using SELOZOK.
Check your reaction to SELOZOK before driving vehicles or operating machines because occasionally may experience dizziness or fatigue (tiredness).
Selozok can cause doping.
Interactions of Selozok
SELOZOK It should be used with caution in patients who are taking the following drugs: antiarrhythmic agents (quinidine and amiodarone), antihistamines, antagonists of the histamine-2 receptor, antidepressants, antipsychotics, COX-2 inhibitors, rifampicin, hydralazine, sympathetic ganglion blockers other beta blockers (including eye drops), MAO inhibitors (MAO), calcium antagonists (diltiazem and verapamil), inhaled anesthetics, indomethacin, other prostaglandin synthetase inhibitors, adrenaline.
If you are taking SELOZOK and clonidine concurrently, do not interrupt the treatment of one of these medications without consulting your doctor.
Alcohol, when used with SELOZOK, metoprolol can increase blood concentrations and thus increase the effects of selozok.
If you are taking hypoglycemics (diabetes medications by mouth), your doctor may need to adjust the dose.
Interference with laboratory tests: using SELOZOK may have elevated serum levels of transaminases, alkaline phosphatase and lactate dehydrogenase (LDH).
Selozok use in pregnancy and breastfeeding
SELOZOK should not be used during pregnancy or lactation unless its use is considered essential. The drug class of beta blockers can cause damage to the fetus and premature labor.
Selozok should not be used by pregnant women without medical or dental surgeon.
Tell your doctor or dentist-surgeon if you are making use of some other medication.
Do not use medication without the knowledge of your doctor. It can be dangerous to your health.DO NOT STOP NOW ... YOU ARE AFTER THAT ADVERTISING;)
5. Where, how and for how long can I keep this medicine?
Storage, manufacturing date, expiry date and physical aspect of Selozok
Store at room temperature (15 ° to 30 ° C).
lot number and dates of manufacture and expiry: see packaging.
Do not use medicine with the expiry date. Store it in its original packaging.
25 mg SELOZOK: white tablets almost white, oval, grooved on both sides and recorded A / ß on one side. The tablets can be divided into equal doses.
50 mg SELOZOK: white tablets almost white, round, ribbed on one side and recorded A / mo other. The groove is only to facilitate tablet division aiding intake and not divided in equal doses.
SELOZOK 100 mg: white tablets almost white, round, ribbed on one side and recorded A / mS another. The groove is only to facilitate tablet division aiding intake and not divided in equal doses.
The tablets and the divided parts should not be chewed or crushed.
Before using, note the appearance of selozok. If it is within the validity period and you observe any changes in appearance, see the pharmacist to find out if you can use it.
All medicine should be kept out of reach of children.DO NOT STOP NOW ... YOU ARE AFTER THAT ADVERTISING;)
6. How should I use this medicine?
Dosage, dosage and usage instructions Selozok
SELOZOK It should be administered once daily orally with liquid may be eaten with meals or on an empty stomach.
- Hypertension: The recommended dosage for patients with mild to moderate hypertension is 50 mg SELOZOK once a day. In patients not responding to 50 mg, the dose may be increased to 100 to 200 mg once a day and / or combined with other antihypertensive agents.
The antihypertensive long-term treatment with daily doses of 100-200 mg metoprolol has been shown to reduce total mortality including sudden cardiovascular death, stroke and coronary events in hypertensive patients.
- Angina pectoris: The recommended dosage is 100-200 mg once daily SELOZOK. If necessary, SELOZOK It can be combined with other anti-anginal agents.
- Chronic heart failure: the dose of SELOZOK It must be adjusted individually in patients with chronic heart failure stabilized with other treatment of heart failure. A recommended starting dose for the first two weeks is a 25 mg tablet once a day. It is recommended that patients with functional class III-IV NYHA start with half a tablet of 25 mg once daily in the first week. It is recommended that the dose is doubled every 2 weeks, up to a maximum dose of 200 mg once a day metoprolol (or until the maximum tolerated dose). During long-term treatment, the aim should be to achieve a dose of 200 mg once a day metoprolol (or the maximum tolerated dose).
At each dose level, patients must be carefully evaluated in terms of tolerability. In case of hypotension, it may be necessary to reduce the concomitant medication. Initial hypotension does not necessarily mean that the dose can not be tolerated in a chronic treatment, but the patient must be maintained at the lowest dose to stabilize.
- Cardiac arrhythmias (abnormal changes in the frequency of heart beats): The recommended dosage is 100-200 mg SELOZOK once a day.
- Maintenance treatment after myocardial infarction: it was demonstrated that long-term treatment with metoprolol in doses of 200 mg, administered once a day reduces the risk of death (including sudden death), and reduces the risk of reinfarction (also in patients with diabetes mellitus).
- functional cardiac disorders with palpitations: the recommended dosage is 100 mg once daily. If necessary, the dose may be increased to 200 mg.
- Prophylaxis of migraine: The recommended dosage is 100-200 mg once a day.
Children: there is limited experience of treating children with SELOZOK.
hepatic failure (abnormal liver function) usually is not necessary to dose adjustment for patients with liver cirrhosis because metoprolol has a low protein binding rate (5% -10%). When there are serious signs of impaired liver function (e.g., patients undergoing bypass surgery), one should consider a dose reduction.
kidney failure (abnormal functioning kidney): no dose adjustment for patients with renal insufficiency.
elderly No dose adjustment.
Follow the guidance of your doctor, always respecting schedules, doses and duration of treatment.
Do not stop treatment without the knowledge of your doctor.
Selozok should not be crushed or chewed.DO NOT STOP NOW ... YOU ARE AFTER THAT ADVERTISING;)
7. What should I do if you forget to use this medicine?
If you forget to take the pill SELOZOK, should take it as well to remember, as long as it at least 12 hours before the next dose. Remember after 12 hours or more, you should take only half of the prescribed dose. The next dose should be taken at the usual time.
If in doubt, seek advice from the pharmacist or your doctor or dentist.DO NOT STOP NOW ... YOU ARE AFTER THAT ADVERTISING;)
8. What are the evils that this medicine can cause me?
Adverse reactions Selozok
- very common reaction (Occurs in 10% or more of patients using selozok) fatigue and asthenia (weakness).
- common reaction (Occurs between 1% and 10% of patients using selozok): bradycardia, postural changes in pressure (very rarely with fainting), cold hands and feet, palpitations, dizziness, headache, nausea, abdominal pain, diarrhea, prison belly and exertional dyspnea (breathlessness on exertion).
- unusual reaction (Is between 0.1% and 1% of patients using selozok): worsening symptoms of heart failure, cardiogenic shock in patients with acute myocardial infarction, heart block first degree, edema (swelling), pain (pain breast), hypotension, paresthesia (tingling), muscle cramps, vomiting, weight gain, depression, difficulty in concentration, drowsiness or insomnia, nightmares, bronchoconstriction (wheezing), rash (in the form of psoriasiform urticaria and dystrophic skin lesions ) and increased sweating.
- rare reaction (Occurs between 0.01% and 0.1% of patients using selozok): abnormal cardiac conduction, cardiac arrhythmias (irregular heart beats), dry mouth, liver function test changes, nervousness, anxiety, impotence / dysfunction sexual, rhinitis, visual disturbance, irritation and / or dryness of the eyes, conjunctivitis and hair loss.
- very rare reaction (Occurs in less than 0,01% of patients using selozok): gangrene (in patients with pre-existing severe peripheral circulation changes), thrombocytopenia (decreased numbers of platelets in the blood) with or without bruising appearance), agranulocytosis (decrease the number of a type of white blood cells (granulocytes) in the blood), thrombocytopenic purpura (acquired blood disease characterized by thrombocytopenia), hepatitis, arthralgia (joint pain), amnesia / memory impairment, confusion, hallucinations, tinnitus, taste disturbances , sensitivity to light and worsening of psoriasis.
Tell your doctor, dentist or pharmacist any undesirable reactions by the use of selozok. Also tell the company through its service.
9. What to do if someone uses a larger amount than indicated this medicine
symptoms: hypotension, acute heart failure, bradycardia and bradyarrhythmias, disturbances in cardiac conduction and bronchospasm
Treatment: It should be held in place with measures of care, adequate monitoring and supervision.
In case of ingestion of a greater amount of drug than prescribed, you should immediately contact your doctor.
In case of use of large amounts of selozok, seek medical help quickly and take the packaging or labeling of selozok if possible. Call 0800 722 6001 if you need further guidance.DO NOT STOP NOW ... YOU ARE AFTER THAT ADVERTISING;)
MS - 1.1618.0077
Farm. . Resp .: Dr. Gisele H. V. C. Teixeira - CRF-SP No. 19825
Manufactured by: AstraZeneca AB (Gärtunavägen) - Sodertalje - Sweden Imported and packed by: AstraZeneca of Brazil Ltda.
. Rod Raposo Tavares, km 26.9 - Cotia - SP - CEP 06707-000
CNPJ 60,318,797 / 0001-00 - Brazilian Industry
SALE UNDER MEDICAL PRESCRIPTION
All trademarks in this package are the property of the AstraZeneca group of companies.
This leaflet was approved by ANVISA on 07/10/2014.
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